Joshua is a registered patent agent with a background in molecular biology. He focuses his practice on drafting and prosecuting US patents for clients in the life sciences industries.
Prior to joining Mintz, Joshua was a postdoctoral research fellow at Harvard Medical School, where he managed a research program using gene-editing and single-cell genomics to assess factors controlling intestinal stem cell proliferation. He designed CRISPR/Cas9 knockout models to study the function of a DNA-binding protein, Zrf1, and its genetic interactions with RISC components. Additionally, Joshua participated in collaborative efforts to develop and validate computational methods for evaluating and prioritizing hypotheses generated from single-cell genomics data. He was also awarded a Croucher Fellowship for Postdoctoral Research for early-career Hong Kong researchers focusing on natural sciences, technology, or medicine.
While earning his PhD at the University of Queensland, Joshua characterized the function and regulation of the cell adhesion molecule, Dscam2, in the context of neurodevelopment. Using an endogenous splicing reporter, he identified Muscleblind as a regulator of cell-type-specific alternative splicing. During his graduate and undergraduate studies, Joshua also served as a teaching assistant.
Publications
- Co-author, The epigenetic factor Zrf1 regulates intestinal stem cell proliferation during midgut regeneration, bioRxiv (Jan 2025)
- Co-author, Gut Tumors in Flies Alter the Taste Valence of An Anti-Tumorigenic Bitter Compound, Current Biology (June 2024)
- Co-author, Prioritizing transcription factor perturbations from single-cell transcriptomics, bioRxiv (February 2023)
- Co-author, FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder, EMBO Molecular Medicine (August 2022)
- Co-author, Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly, Science (March 2022)
- Co-author, FlyPhoneDB: an integrated web-based resource for cell-cell communication prediction in Drosophila, Genetics (March 2022)
- Co-author, Protein Visualization and Manipulation in Drosophila Through the Use of Epitope Tags Recognized by Nanobodies, eLife (January 2022)
Recognition & Awards
Croucher Foundation, Croucher Postdoctoral Fellowship (2019)
Genetics Society of America, DeLill Nasser Award for Professional Development in Genetics (2018)
Genetics Society of Australasia, Spencer-White Award Travel Award (2018)
Involvement
- Genetics Society of America, Peer reviewer (2022 – 2024)